The cost of developing a new drug is continuously rising. Many other factors, such as stricter regulations and stronger global competition, are also creating major challenges. If a pharmaceutical company intends to increase its market share and return on investment, it must consider how to maintain a drug‘s profitability even after its patents have expired. Product Lifecycle Management (PLM) is a viable option for extending profitability, and there are several methods for approaching PLM effectively. What is crucial, however, is to plan for it early on, even, if possible, before the drug actually enters the market.